The short speech is about using your life time, following your passion, love and family.
Video about the speech from abc networks mixed with interview parts, which is the better one. abc-link:
If you do not know who he is, use these links:
Facing his cancer death Randy Pausch gave a couple of very inspiring last lectures. It is much more than just saying use and enjoy your time. You will get a lot of good and substantial advice how to actually do this.
*** The original last lecture "Really achieving your childhood dreams" and the lecture about "Time management" (each more than one hour and the first downloadable with subtitles):